Emzale-DSR

Description

Emzale-DSR is a combination formulation containing esomeprazole gastro-resistant 40 mg and domperidone 30 mg. Esomeprazole reduces stomach acid production, while domperidone helps regulate upper gastrointestinal movement and may help relieve nausea in appropriately selected patients.

Healthcare professionals may consider this combination for selected acid-related gastrointestinal conditions when both ingredients are clinically appropriate. However, domperidone carries a risk of serious heart rhythm disturbances, so treatment requires careful patient selection and medical supervision.

Emzale-DSR is listed in the General Physician (G.P.) and Gynae segments and comes in Alu-Alu packaging of 10 × 10 units.

Therapeutic Segment

Gastroenterology | Acid-Related Disorders | Gastrointestinal Motility

Uses of Emzale-DSR

A healthcare professional may consider this formulation for selected patients who require acid suppression and management of associated gastrointestinal symptoms, depending on the approved product information.

Potential clinical considerations include:

• Gastro-oesophageal reflux symptoms, when the combination is appropriate.
• Acid-related upper gastrointestinal symptoms requiring esomeprazole.
• Nausea associated with selected gastrointestinal conditions, where domperidone is considered suitable and authorised.

The product is not appropriate for every case of acidity, reflux or nausea. Its exact approved indications must be confirmed from the product label and current prescribing guidance.

Key Benefits

• Acid Suppression: Esomeprazole reduces stomach acid production.
• Gastrointestinal Symptom Support: Domperidone may help relieve nausea in selected patients when prescribed appropriately.
• Combination Formulation: Combines two ingredients with different pharmacological actions.
• Alu-Alu Packaging: Provides individual-unit packaging for product protection.

These potential benefits depend on the patient’s condition and the suitability of both ingredients. The combination does not guarantee symptom relief.

How Emzale-DSR Works

Esomeprazole is a proton pump inhibitor (PPI). It suppresses the gastric proton pump in stomach cells, reducing acid secretion.

Domperidone blocks dopamine D2 receptors and can promote upper gastrointestinal motility while helping control nausea. However, it can prolong the QT interval and increase the risk of serious ventricular arrhythmias in susceptible patients.

Possible Side Effects

Possible side effects may include:

• Headache.
• Abdominal discomfort or pain.
• Nausea or diarrhoea.
• Constipation.
• Dry mouth.

Domperidone may also cause serious heart rhythm disturbances, particularly in people with relevant cardiac conditions, electrolyte abnormalities or interacting medicines. Seek urgent medical attention for palpitations, fainting, severe dizziness or chest discomfort.

Long-term or unnecessary use of acid-suppressing medicines can also carry risks. Discuss persistent or severe symptoms with a healthcare professional.

Important Safety Information

• Medical supervision: Use Emzale-DSR only when prescribed and when both ingredients are appropriate.
• Heart-related risk: Domperidone is associated with QT prolongation, serious arrhythmias and sudden cardiac death in susceptible patients.
• Risk factors: Tell your healthcare professional about heart disease, previous arrhythmias, significant electrolyte abnormalities, liver problems and all medicines you take.
• Drug interactions: Domperidone may interact with medicines that prolong the QT interval or strongly inhibit CYP3A4. Do not combine it with interacting medicines without medical review.
• Use restrictions: Domperidone is not suitable for everyone, and its authorised indications, dose and duration may be restricted. Follow current local prescribing guidance.
• Pregnancy and breastfeeding: Consult a healthcare professional before use.
• Warning symptoms: Seek urgent medical assessment for fainting, palpitations or an irregular heartbeat.
• Do not self-medicate: Do not increase the dose or continue treatment longer than prescribed.

Dosage and Administration

Take Emzale-DSR only according to the prescription and approved product label. The appropriate dose, timing and duration depend on the patient’s diagnosis, risk factors and current prescribing guidance.

Do not infer a dosing schedule solely from the strength printed on the pack. Do not take additional doses to compensate for a missed dose without checking the product instructions or consulting a healthcare professional.

Storage Instructions

Store Emzale-DSR according to the conditions stated on the approved product label. Keep the medicine in its original packaging, away from children, and do not use it after the expiry date.