Pantanu-DSR

Description

Pantanu-DSR is a combination formulation containing pantoprazole sodium 40 mg and sustained-release (SR) domperidone 30 mg. It combines acid suppression with an antiemetic and prokinetic action and may be prescribed for selected gastrointestinal conditions when both ingredients are considered appropriate.

Pantoprazole helps reduce stomach acid production, while domperidone may help relieve nausea and support upper gastrointestinal motility. However, domperidone carries a risk of serious heart rhythm problems, so a healthcare professional must assess whether this combination is suitable for each patient.

Therapeutic Segment

Gastrointestinal Care | Acid Reflux Management | Prescription Digestive Care

Uses of Pantanu-DSR

A healthcare professional may prescribe Pantanu-DSR for selected acid-related gastrointestinal conditions when both ingredients are clinically appropriate, such as:

• Gastroesophageal reflux symptoms.
• Acid-related discomfort accompanied by nausea.
• Selected upper gastrointestinal symptoms for which acid suppression and prokinetic treatment are considered appropriate.

The precise indication depends on the patient’s diagnosis and the approved product information.

Key Benefits

• Acid suppression: Pantoprazole reduces gastric acid production.
• Nausea relief: Domperidone may help manage nausea and vomiting in suitable patients.
• Motility support: Domperidone supports upper gastrointestinal movement.
• Combination formulation: Brings together two different mechanisms of action in one product.

These effects do not guarantee symptom relief for every patient. Treatment should be based on a healthcare professional’s assessment.

How Pantanu-DSR Works

Pantoprazole sodium 40 mg belongs to the proton pump inhibitor (PPI) class. It reduces stomach acid secretion by inhibiting the proton pumps involved in acid production.

Domperidone SR 30 mg is a dopamine receptor antagonist with prokinetic and antiemetic effects. It can support upper gastrointestinal motility and help relieve nausea. However, domperidone can prolong the QT interval and increase the risk of serious cardiac arrhythmias in susceptible patients, particularly when interacting medicines are used.

Possible Side Effects

Possible side effects may include:

• Headache
• Abdominal discomfort
• Diarrhoea or constipation
• Nausea
• Dry mouth

Domperidone may also cause elevated prolactin levels, which can sometimes lead to breast tenderness, breast milk production or menstrual changes.

Important cardiac warning: Seek urgent medical attention for fainting, a rapid or irregular heartbeat, or severe dizziness. The risk may be higher in people with certain heart conditions, electrolyte disturbances or interacting medicines.

Important Safety Information

• Use Pantanu-DSR only under the supervision of a qualified healthcare professional.
• Domperidone may not be suitable for people with certain heart rhythm disorders, significant electrolyte abnormalities or moderate to severe liver impairment.
• Tell your prescriber about all medicines you take, especially medicines that prolong the QT interval or strongly inhibit CYP3A4.
• Do not combine domperidone with medicines that may cause clinically significant interactions without professional review.
• Inform your healthcare professional if you take clopidogrel or other medicines that may interact with pantoprazole.
• Use domperidone at the lowest effective dose for the shortest duration recommended by the prescriber and applicable guidance.
• Seek medical advice for persistent symptoms, difficulty swallowing, unexplained weight loss, vomiting blood or black stools.
• Do not adjust the dose or treatment duration on your own.

Dosage and Administration

Take Pantanu-DSR only as prescribed and follow the approved product label. The appropriate timing and duration depend on the patient’s diagnosis, medical history and other medicines.

Because the formulation contains sustained-release domperidone, follow the product-specific instructions. Do not crush, chew or open the dosage form unless the approved instructions specifically allow it.

Storage Instructions

Store Pantanu-DSR according to the conditions stated on the approved product packaging. Keep it in its original Alu-Alu pack, protected from excessive heat and moisture, and out of reach of children. Confirm the exact storage requirements from the product label.